Our Science-backed Metabolic Protocol for Cardiac Patients addresses the true root causes of diastolic dysfunction and microvascular rarefaction. By focusing on metabolic imbalances like insulin resistance, mitochondrial dysfunction, chronic inflammation, and oxidative stress, we help restore your heart’s flexibility, rebuild its microvascular network, and reverse the silent progression of heart failure with preserved ejection fraction (HFpEF).
What We’ve Learned About INDIAN HEARTS:
- Cardiovascular treatments in India have mirrored a Western paradigm, primarily focusing on “pumping disorders” like systolic dysfunction. Yet, here in India, a different and equally dangerous silent epidemic is unfolding.
- Our population faces a heightened predisposition to a subtler, more insidious form of heart disease, one rooted not in the heart’s pumping strength, but in its fundamental metabolic health.
- We see the evidence in the rising numbers of Heart Failure with Preserved Ejection Fraction (HFpEF) cases in India – a condition where the heart’s pumping function appears normal, but its ability to relax and fill with blood is severely impaired.
This isn’t a problem of weakened muscle; it’s a metabolic and microvascular crisis.
Selected Research Supporting Our Metabolic Approach
Explore a curated selection of peer-reviewed studies that support our integrative heart care philosophy.
- Prevalence of Diastolic Dysfunction in Type 2 Diabetes Mellitus (M. K. et al (2017) JEBMH
- Normotensive Type 2 diabetics under 45 show significant rates of diastolic dysfunction (Sukhwani N. et al.,2020) DOI:10.17511/ijmrr.2020.i06.08
- A 2016 study on the prevalence of diastolic dysfunction in type 2 diabetes mellitus (T. K. V. Sharavanan. et al., 2016) IAIM: 322924174
- Prevalence of diastolic dysfunction in Hypertensive Patients: A 2021 study found that there’s an unexpectedly high prevalence of different forms of diastolic dysfunction in treated hypertensive patients who are free of overt cardiovascular disease. (P Krishnarajan. et al.,2021) DOI: 10.36106/ijar
- Left Ventricular Diastolic Dysfunction in Type 2 Diabetes and Its Association with Glycemic Control (HbA1c): (Lavina P. et al., 2023) DOI: 10.22159/ajpcr.48474
- Subclinical Hypothyroidism and Its Association with Left Ventricular Diastolic Dysfunction: (Ankit J. et al., 2021) IJHCR:1883
- Prevalence of Left Ventricular Diastolic Dysfunction in a General Population (T Kuznetsova. et al., 2021)
DOI: 10.1161/circheartfailure.108.822627 - Prevalence & correlates of diastolic dysfunction in patients with hypertension (S. Al-Ghamdi. et al., 2021)
DOI: 10.11604/pamj.2021.40.159.31089 - Predictors of diastolic dysfunction in ethnic groups: Observations from the Hypertensive Cohort of The Ethnic-Echocardiographic Heart of England Screening Study (E-ECHOES) (Alena S. et al., 2021) PMID: 29713052
- Capillary rarefaction might be an independent risk marker for cardiovascular disease in South Asians: (V. Nama. et al., 2011) PMID: 21289648
- Microcirculatory rarefaction in South Asians is a potential mechanism for increased cardiovascular risk and diabetes: (Alun D. Hughes. et al., 2013) PMID: 24116136
Further Scientific Evidence & Publications
| M. Fischer. et. al., 2003 EHJ: 2733901 | Abdul L M. et. al., 2004 PMID: 22977362 |
| Selma F. M. et. al., 2014 AHA: 009625 | Laura J. R-Torvik. et. al., 2017 AJE: 3769382 |
| Matthew N. et. al., 2018 JAHA:008291 | Heng Zeng. et. al., 2019 fcvm.2019.00015 |
| Maud v. D. et. al., 2023 PMID: 36646051 | W.J Wang. et. al., 2024 fphar.2024.1346905 |
| Duncan J. C. et. al., 2024 JAHA: 037332 | Mayuresh. C. et. al., 2025 MDPI: 14145002 |
That’s the gap we fill at CFOH.
We go beyond ejection fraction — to restore true heart function from the inside out.
The Role of Metabolism in Diastolic Dysfunction & Microvascular Rarefaction
One major yet under-recognized driver of diastolic dysfunction is mitochondrial dysfunction. The heart, being the most mitochondria-rich organ, depends on these energy-producing structures for its constant contractions and relaxations. When mitochondria weaken—due to aging, illness, or metabolic stress—the heart struggles to relax properly despite having normal pumping strength. Alongside this, chronic inflammation from insulin resistance, obesity, or toxin exposure leads to myocardial fibrosis, where the heart tissue stiffens due to excess collagen, reducing its ability to fill efficiently between beats.
Additional metabolic stressors worsen the condition. Lipotoxicity, common in metabolic syndrome and diabetes, results in fat deposits within heart muscle cells, impairing both energy production and mechanical movement. On top of that, elevated blood sugar levels lead to the formation of Advanced Glycation End-products (AGEs), which stiffen the heart further by cross-linking collagen and other proteins. Together, these silent processes gradually rob the heart of its flexibility and resilience.
This isn’t about a weak heart — it’s a heart that’s metabolically exhausted and inflamed.
The tiny blood vessels that nourish your heart — the microvasculature — depend on a healthy inner lining called the endothelium. When this lining becomes inflamed due to poor metabolic health, it loses its ability to produce nitric oxide, a molecule essential for blood vessel dilation and repair. As nitric oxide declines, blood flow decreases, new vessel growth slows, and oxygen delivery to the heart suffers. At the same time, insulin resistance — common in metabolic syndrome — thickens the capillary walls, further disrupting nutrient exchange and promoting gradual vessel closure. This ongoing damage leads to microvascular rarefaction, a silent loss of the smallest yet most vital blood vessels in your heart.
Adding to this is chronic inflammation, often triggered by environmental toxins, infections, or poor gut health, which impairs the body’s natural ability to repair and regenerate capillaries. On a deeper cellular level, oxidative stress from dysfunctional mitochondria releases excess reactive oxygen species (ROS) — damaging vessel walls and overwhelming antioxidant defenses. Together, these forces shrink your heart’s internal vascular network, quietly starving your heart cells — even when larger arteries appear clear on tests.
CFOH: REVERSING DISEASES FROM ITS ROOT
At CFOH, We Don’t Just Manage Cardiovascular Disease — We Work to Reverse It. We believe that lasting recovery is possible when we address the true root causes — not just the symptoms. Our protocol is built around deep investigation, precision care, and cellular-level healing. We look into your metabolism, microcirculation, and inflammatory terrain — the hidden systems silently shaping your heart’s future.
The Bio-terrain Audit:
A Deep Dive Into Your Internal Ecosystem
We begin with a comprehensive analysis of your unique biological landscape — what we call your “bioterrain.”
This includes metabolic function, inflammatory markers, microvascular integrity, toxin burden, mitochondrial health, and more. We consider your genetics, lifestyle, diet, environment, and past history — because your heart health is shaped by more than just numbers on a report.
Targeted Therapeutic Programs:
Built for Your Biology
Based on your audit findings, we design a precisely tailored treatment plan to address early or hidden signs of cardiovascular disease.
From enhancing diastolic flexibility and promoting microvascular regeneration to restoring energy metabolism, every intervention supports your body’s natural capacity to heal.
Prevention Meets Restoration:
Not Just Maintenance
Our goal isn’t to “control” your heart condition — it’s to help you heal and thrive.
With education, lifestyle guidance, and regenerative support, we give you the tools to prevent future complications and reclaim lasting cardiovascular vitality.
WHAT OUR PATIENTS ARE SAYING
” Bio-terrain Audit revealed my heart wasn’t pumping poorly — it was filling poorly. Diastolic dysfunction was never even mentioned by my previous doctors. Their root-cause protocol changed my life. My energy is back. I can enjoy walks again without fear. “
– Karan Taneja, 51- Chandigarh
“Dr. Anupam Gaur helped me understand that heart disease is not just about blockages — it’s about your entire internal environment. Their Bio-terrain Audit uncovered inflammation, toxic load, & metabolic stress that were silently pushing me toward heart failure. The metabolic program they built for me was tailored to the root causes, not just the symptoms. This is the future of heart care.”
– Sunita Dahiya, 42- Mumbai
“I came to CFOH after recovering from COVID, but I never felt the same again. Breathlessness, palpitations, brain fog — & no one had answers. Bio-terrain Audit found clear signs of microvascular damage & lingering metabolic dysfunction. Their regenerative protocol addressed everything from nutrition to oxygenation. I’m three months in & I finally feel like myself again.”
– Rajiv Pal, 39- Faridabad
“When you live with chronic heart symptoms, you start believing this is just your new normal. But Dr. Anupam Gaur gave me hope. Their Bio-terrain Audit was so detailed — I discovered issues in my mitochondria, inflammation, & even toxin exposure. Their program wasn’t just a treatment plan — it felt like a reset for my entire body. I’m healing at a pace I never thought possible.”
– Dimple Singh, 47- Delhi
“For years I was told my heart was fine because my ejection fraction looked normal. Constantly out of breath, tired, & anxious. CFOH was the first place that didn’t brush me off. Through Bio-terrain Audit, they found inflammation markers & microvascular damage that no one had even checked for. Since starting their metabolic protocol, I sleep better, walk further, & feel like I’m aging backward.”
– Ajit, 60- Jaipur
“Before coming to CFOH, I was on five heart medications, & none of them made me feel better — only more dependent. Bio-terrain Audit was unlike anything I’ve experienced. It wasn’t just a test. It was a revelation. They showed me how my poor Bio-Terrain was quietly damaging my heart. It helped reduce my meds, improved my stamina, & I finally feel in control of my health again.”
– Sonia Maniar, 50- Gurgaon
Take the First Step Toward Root-Cause Heart Healing
Book Your Comprehensive Bio-terrain Audit — a deep, science-backed assessment of your cardiovascular terrain.
Whether you’re just beginning, exploring your options, or ready for a personalized plan — you’re in the right place. Select the path that suits your current needs.